Produit
CAT:
CCP1386-01
Taille:
1 mg
Prix:
Connecter vous pour voir le prix
Qty:
Disponibilité et expédition
- Articles en stock livrables sous 24 à 48 heures et articles hors stock livrables sous 2 à 6 semaines
- Glace carbonique: Non requis
Description du produit
Peptide to Prion Peptide (106-126), Human
Propriétés du produit
Dangereuxnon
Glace carbonique requisenon
Marque déposéenon
Informations complémentaires
Cas: 148439-49-0
Structure Composition: H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH
Applications: An altered form of the large cellular prion protein accumulates in the CNS of patients with neurodegenerative disorders, and its protease-resistant core aggregates extracellularly into amyloid fibrils. This process is accompanied by nerve cell loss. The 21-peptide KTNMKHMAGAAAAGAVVGGLG is used as a model to investigate neurodegeneration in prion diseases. Prion Protein (106-126) forms fibrils in vitro and causes apoptotic cell death in neuron culture. Its neurotoxicity depends on the presence of microglia and is induced by microglia. It could be demonstrated that KTNMKHMAGAAAAGAVVGGLG is able to bind to DNA, a circumstance which led to the assumption that the integral protein could also bind to DNA under appropriate solution conditions.
Purity: > 95%
Form: Lyophilized powder
Molecular Formula: C80H138N26O24S2
Molecular Weight: 1912.28
Conditions de stockage: Shipped at 4°C. Store at -20°C for one year.
Light Source: Synthetic
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